Yuan Chang, MD
- Distinguished Professor, Department of Pathology
- American Cancer Society Research Professor
- UPMC Endowed Chair in Cancer Virology
Academic Appointments
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2002-present
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Professor of Pathology
Department of Pathology University of Pittsburgh Pittsburgh, Pennsylvania |
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2000-2002
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Professor of Pathology
Department of Pathology Columbia University College of Physicians & Surgeons New York, New York |
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1997-2000
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Associate Professor of Pathology
Department of Pathology Columbia University College of Physicians & Surgeons New York, New York |
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1993-1997
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Assistant Professor of Pathology
Department of Pathology Columbia University College of Physicians & Surgeons New York, New York |
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1991-1992
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Clinical Instructor
Department of Pathology Stanford University Medical Center Stanford, California |
Prior Experience
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2000-2002
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Attending Pathologist
Department of Pathology Presbyterian Hospital New York, New York |
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1997-2000
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Associate Attending
Department of Pathology Presbyterian Hospital New York, New York |
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1993-1997
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Assistant Attending
Department of Pathology Presbyterian Hospital New York, New York |
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1991-1992
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Visiting Scientist
DNAX Research Institute of Molecular Biology Palo Alto, |
Education and Training:
1981 BS - Stanford University
1987 MD - University of Utah College of Medicine
1989 Resident - Anatomic Pathology – Univ California, San Francisco
1991 Fellow - Neuropathology – Stanford University Medical School
Awards and Honors:
1995 James S. McDonnell Scholar Award, St. Louis, MO
1997 Meyenburg Award, Meyenburg Foundation for Cancer Research, German Cancer Research Center
1998 Robert Koch Prize, Robert Koch Foundation, Bonn, Germany
2003 Charles S. Mott Award, General Motors Cancer Research Foundation
2003 Paul Marks Prize, Memorial Sloan Kettering Cancer Center, NY, NY
2008 American Cancer Society Research Professorship
2012 Marjory Stephenson Prize, Society for General Microbiology (SGM), UK
2012 Chancellor’s Distinguished Research Award, University of Pittsburgh
2012 Distinguished Professorship, University of Pittsburgh
2013 Endowed Chair in Cancer Virology, University of Pittsburgh
2015 National Cancer Advisory Board (NCAB), Presidential Appointment
2017 Passano Foundation Award, The Passano Foundation
2017 Paul Ehrlich-Ludwig Darmstaedter Prize, Paul Ehrlich Foundation
2019 NCI Director’s Career Achievement Award
Membership in Honorary Societies:
2004 American Society for Clinical Investigation (ASCI), Elected Member
2010 American Academy of Microbiology (AAM), Elected Fellow
2012 National Academy of Sciences (NAS), Elected Member
2014 Association of American Physicians (AAP), Elected Member
Selected Publications:
Chang Y, Cesarman E, Pessin MS, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi’s sarcoma. Science 1994; 265:1865-69.
Moore PS and Chang Y. Detection of herpesvirus-like DNA sequences in Kaposi’s sarcoma from persons with and without HIV infection. New Eng. J. Med., 1995; 332:1181-85.
Gao SJ, Kingsley L, Hoover D, Spira T, Rinaldo C, Saah A, Phair J, Detels R, Parry P, Chang Y, Moore PS. Seroconversion to antibodies against Kaposi’s sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi’s sarcoma. New Eng. J. Med., 1996; 335:233-41.
Russo JJ, Bohenzky RA, Chien M, Chen K, Yan M, Maddalena D, Parry JP, Peruzzi D, Edelman IS, Chang Y, Moore PS. The nucleotide sequence of Kaposi’s sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci, USA 1996; 93:148627.
Moore PS, Boshoff C, Weiss RA, Chang Y. Molecular mimicry of human cytokine and cytokine-response pathway genes by KSHV. Science 1996; 274:1739-44.
Chang Y, Moore PS, Talbot SJ, Boshoff CH, Zarkowska T, Godden-Kent, Paterson H, Weiss RA, Mittnacht S. Cyclin encoded by KS herpesvirus. Nature 1996; 382:410.
Sarid R, Sato T, Bohenzky RA, Russo JJ, Chang Y. Kaposi’s sarcoma-associated herpesvirus encodes a functional bcl-2 homologue. Nature Med 1997; 3:293-8.
Boshoff C, Endo Y, Collins PD, Takeuchi Y, Reeves JD, Schweickart VL, Siani M, Sasaki T, Williams TJ, Gray PW, Moore PS, Chang Y, Weiss RA.Angiogenic and HIV inhibitory functions of KSHV-encoded chemokines. Science 1997; 278:290-294.
Chatterjee M, Osborne J, Bestetti G, Chang Y. Moore PS. Viral IL-6-Induced Cell Proliferation and Immune Evasion of Interferon Activity. Science 2002; 298:1432-5.
Feng H, Shuda M, Chang Y and Moore PS. Clonal Integration of a Polyomavirus in Merkel Cell Carcinoma. Science 2008 319(5866): 1096-1100.
Shuda M, Feng H, Kwun H, Rosen ST, Gjoerup O, Moore PS, Chang Y. T-antigen mutations are a tumor-specific signature for Merkel cell polyomavirus. Proc Natl Acad Sci, USA 2008 21;105(42):16272-7.
Shuda M, Velásquez C., Cheng E., Cordek DG, Kwun HJ, Chang Y, Moore PS. CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation. Proc Natl Acad Sci, USA 2015 May 12;112(19):5875-82.
Toptan T, Abere B, Nalesnik MA, Swerdlow SH, Ranganathan S, Lee N, Shair KH, Moore PS, Chang Y.Circular DNA tumor viruses make circular RNAs. Proc Natl Acad Sci, USA 2018 Sept 11;115(37):E8737-E8745.