Yuan Chang, MD

  • American Cancer Society Research Professor
  • Distinguished Professor, Dept. of Pathology
  • Chair of Cancer Virology

Academic Appointments

2002-present
Professor of Pathology
Department of Pathology
University of Pittsburgh
Pittsburgh, Pennsylvania
2000-2002
Professor of Pathology
Department of Pathology
Columbia University College of Physicians & Surgeons
New York, New York
1997-2000
Associate Professor of Pathology
Department of Pathology
Columbia University College of Physicians & Surgeons
New York, New York
1993-1997
Assistant Professor of Pathology
Department of Pathology
Columbia University College of Physicians & Surgeons
New York, New York
1991-1992
Clinical Instructor
Department of Pathology
Stanford University Medical Center
Stanford, California

Prior Experience

2000-2002
Attending Pathologist
Department of Pathology
Presbyterian Hospital
New York, New York
1997-2000
Associate Attending
Department of Pathology
Presbyterian Hospital
New York, New York
1993-1997
Assistant Attending
Department of Pathology
Presbyterian Hospital
New York, New York
1991-1992
Visiting Scientist
DNAX Research Institute of Molecular Biology
Palo Alto,

Education and Training:

1981                BS - Stanford University
1987                MD - University of Utah College of Medicine
1989                Resident  - Anatomic Pathology – Univ California, San Francisco
1991                Fellow -  Neuropathology – Stanford University Medical School

Awards and Honors:

1995                   James S. McDonnell Scholar Award, St. Louis, MO
1997                   Meyenburg Award, Meyenburg Foundation for Cancer Research German Cancer Research Center
1998                   Robert Koch Prize, Robert Koch Foundation, Bonn, Germany
2003                   Charles S. Mott Award, General Motors Cancer Research Foundation
2003                   Paul Marks Prize, Memorial Sloan Kettering Cancer Center, NY, NY
2008                   American Cancer Society Research Professorship
2010                   Howard Taylor Ricketts Award, University of Chicago
2012                   Marjory Stephenson Prize, Society for General Microbiology (SGM), UK
2012                   Chancellor’s Distinguished Research Award, University of Pittsburgh
2012                   Distinguished Professorship, University of Pittsburgh
2013                   Endowed Chair in Cancer Virology, University of Pittsburgh
2015                   National Cancer Advisory Board (NCAB), Presidential Appointment
2017                   Passano Foundation Award, The Passano Foundation
2017                   Paul Ehrlich-Ludwig Darmstaedter Prize, Paul Ehrlich Foundation
2019                   NCI Director’s Career Achievement Award

Membership in Honorary Societies:

2004                   American Society for Clinical Investigation (ASCI), Elected Member
2010                   American Academy of Microbiology (AAM), Elected Fellow
2012                   National Academy of Sciences (NAS), Elected Member
2014                   Association of American Physicians (AAP), Elected Member

Selected Publications:

Chang Y, Cesarman E, Pessin MS, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi’s sarcoma. Science 1994; 265:1865-69.

Moore PS and Chang Y. Detection of herpesvirus-like DNA sequences in Kaposi’s sarcoma from persons with and without HIV infection. New Eng. J. Med., 1995; 332:1181-85.

Gao SJ, Kingsley L, Hoover D, Spira T, Rinaldo C, Saah A, Phair J, Detels R, Parry P, Chang Y, Moore PS. Seroconversion to antibodies against Kaposi’s sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi’s sarcoma. New Eng. J. Med., 1996; 335:233-41.

Russo JJ, Bohenzky RA, Chien M, Chen K, Yan M, Maddalena D, Parry JP, Peruzzi D, Edelman IS, Chang Y, Moore PS. The nucleotide sequence of Kaposi’s sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci, USA 1996; 93:148627.

Moore PS, Boshoff C, Weiss RA, Chang Y. Molecular mimicry of human cytokine and cytokine-response pathway genes by KSHV. Science 1996; 274:1739-44.

Chang Y, Moore PS, Talbot SJ, Boshoff CH, Zarkowska T, Godden-Kent, Paterson H, Weiss RA, Mittnacht S. Cyclin encoded by KS herpesvirus. Nature 1996; 382:410.

Sarid R, Sato T, Bohenzky RA, Russo JJ, Chang Y. Kaposi’s sarcoma-associated herpesvirus encodes a functional bcl-2 homologue. Nature Med 1997; 3:293-8.

Boshoff C, Endo Y, Collins PD, Takeuchi Y, Reeves JD, Schweickart VL, Siani M, Sasaki T, Williams TJ, Gray PW, Moore PS, Chang Y, Weiss RA.Angiogenic and HIV inhibitory functions of KSHV-encoded chemokines. Science 1997; 278:290-294.

Chatterjee M, Osborne J, Bestetti G, Chang Y. Moore PS. Viral IL-6-Induced Cell Proliferation and Immune Evasion of Interferon Activity. Science 2002; 298:1432-5.

Feng H, Shuda M, Chang Y and Moore PS. Clonal Integration of a Polyomavirus in Merkel Cell Carcinoma. Science 2008 319(5866): 1096-1100.

Shuda M, Feng H, Kwun H, Rosen ST, Gjoerup O, Moore PS, Chang Y. T-antigen mutations are a tumor-specific signature for Merkel cell polyomavirus. Proc Natl Acad Sci, USA 2008 21;105(42):16272-7.

Shuda M, Velásquez C., Cheng E., Cordek DG, Kwun HJ, Chang Y, Moore PS.  CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation. Proc Natl Acad Sci, USA 2015 May 12;112(19):5875-82.

Toptan T, Abere B, Nalesnik MA, Swerdlow SH, Ranganathan S, Lee N, Shair KH, Moore PS, Chang Y.Circular DNA tumor viruses make circular RNAs. Proc Natl Acad Sci, USA 2018 Sept 11;115(37):E8737-E8745.