We are working hard to make new discoveries about Merkel Cell Polyomavirus. If you or someone you love has been diagnosed with MCC, check out our page for patients and friends for resources and information.

 

 

 

 

KSHV LANA generates novel cytoplasmic proteins through non canonical translation initiation J Virol. 2012 Dec 19

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Dr. Reety Arora defends her PhD thesis and publishes a killer paper in Science Translational Medicine. Congratulations, Reety! Badhai ho!

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Check out Human Herpesviruses:

Yuan Chang, MD

Patrick Moore

American Cancer Society Research Professor
Professor, Department of Pathology

Office Phone: 412-623-7721, -7716
Lab Phone: 412-623-7733
Fax: 412-623-7715
Email: yc70@pitt.edu

Lab Address:
Hillman Cancer Research Pavilion
Suite 1.8
5117 Centre Ave.
Pittsburgh, PA 15213

 

 


ACADEMIC APPOINTMENTS:

2002-present

Professor of Pathology
Department of Pathology
University of Pittsburgh
Pittsburgh, Pennsylvania

2000-2002 Professor of Pathology
Department of Pathology
Columbia University College of Physicians & Surgeons
New York, New York
1997-2000 Associate Professor of Pathology
Department of Pathology
Columbia University College of Physicians & Surgeons
New York, New York
1993-1997 Assistant Professor of Pathology
Department of Pathology
Columbia University College of Physicians & Surgeons
New York, New York
1991-1992 Clinical Instructor
Department of Pathology
Stanford University Medical Center
Stanford, California

PRIOR EXPERIENCE:

2000-2002 Attending Pathologist
Department of Pathology
Presbyterian Hospital
New York, New York
1997-2000 Associate Attending
Department of Pathology
Presbyterian Hospital
New York, New York
1993-1997 Assistant Attending
Department of Pathology
Presbyterian Hospital
New York, New York
1991-1992 Visiting Scientist
DNAX Research Institute of Molecular Biology
Palo Alto, CA

Biosketch: coming soon......

Selected Publications:

  1. Chang Y, Cesarman E, Pessin MS, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 1994; 265:1865-69.
  2. Moore PS and Chang Y. Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma from persons with and without HIV infection. New Eng. J. Med., 1995; 332:1181-85.
  3. Gao SJ, Kingsley L, Hoover D, Spira T, Rinaldo C, Saah A, Phair J, Detels R, Parry P, Chang Y, Moore PS. Seroconversion to antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcoma. New Eng. J. Med., 1996; 335:233-41.
  4. Gao SJ, Kingsley L, Li M, Zhang W, Parravicini C, Ziegler J, Newton R, Rinaldo CR, Saah A, Phair J, Detels R, Chang Y, Moore PS KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma. Nature Medicine 1996; 2:925-28.
  5. Russo JJ, Bohenzky RA, Chien M, Chen K, Yan M, Maddalena D, Parry JP, Peruzzi D, Edelman IS, Chang Y, Moore PS. The nucleotide sequence of Kaposi's sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci, USA 1996; 93:148627.
  6. Moore PS, Boshoff C, Weiss RA, Chang Y. Molecular mimicry of human cytokine and cytokine-response pathway genes by KSHV. Science 1996; 274:1739-44.
  7. Chang Y, Moore PS, Talbot SJ, Boshoff CH, Zarkowska T, Godden-Kent, Paterson H, Weiss RA, Mittnacht S. Cyclin encoded by KS herpesvirus. Nature 1996; 382:410.
  8. Sarid R, Sato T, Bohenzky RA, Russo JJ, Chang Y. Kaposi's sarcoma-associated herpesvirus encodes a functional bcl-2 homologue. Nature Med 1997; 3:293-8.
  9. Gao SJ, Boshoff C, Jayachandra S, Weiss RA, Chang Y, Moore PS. KSHV ORF K9 (vIRF) is an oncogene that inhibits the interferon signaling pathway. Oncogene 1997; 15:1979-86.
  10. Chatterjee M, Osborne J, Bestetti G, Chang Y. Moore PS. Viral IL-6-Induced Cell Proliferation and Immune Evasion of Interferon Activity. Science 2002; 298:1432-5.
  11. Feng H, Shuda M, Chang Y and Moore PS. Clonal Integration of a Polyomavirus in Merkel Cell Carcinoma. Science 2008 319(5866): 1096-1100.
  12. Shuda M, Feng H, Kwun H, Rosen ST, Gjoerup O, Moore PS, Chang Y. T-antigen mutations are a tumor-specific signature for Merkel cell polyomavirus. Proc Natl Acad Sci, USA. 2008 21;105(42):16272-7.
  13. Shuda, M., Kwun, H. J., Feng, H., Chang, Y., & Moore, P. S. Merkel Cell Polyomavirus Small T Antigen Is a PP2A-independent Human Oncoprotein Targeting the Translation Regulator 4E-BP1. J Clin Invest, 2011 doi:10.1172/JCI46323.