Yuan Chang, MD
American Cancer Society Research Professor
Professor, Department of Pathology
Office Phone: 412-623-7721, -7716
Lab Phone: 412-623-7733
Fax: 412-623-7715
Email: yc70@pitt.edu
Lab Address:
Hillman Cancer Research Pavilion
Suite 1.8
5117 Centre Ave.
Pittsburgh, PA 15213
ACADEMIC APPOINTMENTS:
| 2002-present | Professor of Pathology |
| 2000-2002 | Professor of Pathology Department of Pathology Columbia University College of Physicians & Surgeons New York, New York |
| 1997-2000 | Associate Professor of Pathology Department of Pathology Columbia University College of Physicians & Surgeons New York, New York |
| 1993-1997 | Assistant Professor of Pathology Department of Pathology Columbia University College of Physicians & Surgeons New York, New York |
| 1991-1992 | Clinical Instructor Department of Pathology Stanford University Medical Center Stanford, California |
PRIOR EXPERIENCE:
| 2000-2002 | Attending Pathologist Department of Pathology Presbyterian Hospital New York, New York |
| 1997-2000 | Associate Attending Department of Pathology Presbyterian Hospital New York, New York |
| 1993-1997 | Assistant Attending Department of Pathology Presbyterian Hospital New York, New York |
| 1991-1992 | Visiting Scientist DNAX Research Institute of Molecular Biology Palo Alto, CA |
Biosketch: coming soon......
Selected Publications:
- Chang Y, Cesarman E, Pessin MS, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 1994; 265:1865-69.
- Moore PS and Chang Y. Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma from persons with and without HIV infection. New Eng. J. Med., 1995; 332:1181-85.
- Gao SJ, Kingsley L, Hoover D, Spira T, Rinaldo C, Saah A, Phair J, Detels R, Parry P, Chang Y, Moore PS. Seroconversion to antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcoma. New Eng. J. Med., 1996; 335:233-41.
- Gao SJ, Kingsley L, Li M, Zhang W, Parravicini C, Ziegler J, Newton R, Rinaldo CR, Saah A, Phair J, Detels R, Chang Y, Moore PS KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma. Nature Medicine 1996; 2:925-28.
- Russo JJ, Bohenzky RA, Chien M, Chen K, Yan M, Maddalena D, Parry JP, Peruzzi D, Edelman IS, Chang Y, Moore PS. The nucleotide sequence of Kaposi's sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci, USA 1996; 93:148627.
- Moore PS, Boshoff C, Weiss RA, Chang Y. Molecular mimicry of human cytokine and cytokine-response pathway genes by KSHV. Science 1996; 274:1739-44.
- Chang Y, Moore PS, Talbot SJ, Boshoff CH, Zarkowska T, Godden-Kent, Paterson H, Weiss RA, Mittnacht S. Cyclin encoded by KS herpesvirus. Nature 1996; 382:410.
- Sarid R, Sato T, Bohenzky RA, Russo JJ, Chang Y. Kaposi's sarcoma-associated herpesvirus encodes a functional bcl-2 homologue. Nature Med 1997; 3:293-8.
- Gao SJ, Boshoff C, Jayachandra S, Weiss RA, Chang Y, Moore PS. KSHV ORF K9 (vIRF) is an oncogene that inhibits the interferon signaling pathway. Oncogene 1997; 15:1979-86.
- Chatterjee M, Osborne J, Bestetti G, Chang Y. Moore PS. Viral IL-6-Induced Cell Proliferation and Immune Evasion of Interferon Activity. Science 2002; 298:1432-5.
- Feng H, Shuda M, Chang Y and Moore PS. Clonal Integration of a Polyomavirus in Merkel Cell Carcinoma. Science 2008 319(5866): 1096-1100.
- Shuda M, Feng H, Kwun H, Rosen ST, Gjoerup O, Moore PS, Chang Y. T-antigen mutations are a tumor-specific signature for Merkel cell polyomavirus. Proc Natl Acad Sci, USA. 2008 21;105(42):16272-7.
- Shuda, M., Kwun, H. J., Feng, H., Chang, Y., & Moore, P. S. Merkel Cell Polyomavirus Small T Antigen Is a PP2A-independent Human Oncoprotein Targeting the Translation Regulator 4E-BP1. J Clin Invest, 2011 doi:10.1172/JCI46323.