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MCV & KSHV Publications

Some Recent Chang-Moore Lab Publications On The Web (partial list - for full list see KSHV endnote download in Research Tools page)

Moschos S, Chang Y, and Moore PS. Merkel Cell Polyomavirus: The Seventh Human Cancer Virus? The Melanoma Letter, 2009. In Press.

Kwun HJ, Guastafierro A, Shuda M, Meinke G, Bohm A, Moore PS, and Chang Y. The minimum replication origin of Merkel cell polyomavirus has a unique large T antigen loading architecture and requires small T antigen expression for optimal replication. Journal of Virology, 2009. In Press. Full text

Reisinger DM, Shiffer JD, Cognetta Jr. AB, Chang Y, and Moore PS. Lack of evidence for basal or squamous cell carcinoma infection with Merkel cell polyomavirus in immunocompetent patients with Merkel cell carcinoma, J Am Acad Dermatol, 2009. In Press

Busam K, Jungbluth AA, Rekhtman N, Coit D, Pulitzer M, Bini JM, Arora R, Hanson NC, Tassello JA, Frosina D, Moore PS, Chang Y. Merkel cell polyomavirus expression in merkel cell carcinomas and its absence in combined tumors and pulmonary neuroendocrine carcinomas. Am J Surg Path, 2009. In press

Pastrana, DV, Tolstov YL, Becker JC, Moore PS, Chang Y, and Buck CB. Quantitation of human seroresponsiveness to Merkel cell polyomavirus. PLoS Pathog, 2009. In Press. Full text

Tolstov Y, Pastrana D, Feng H, Becker J, Jenkins F, Moschos S, Chang Y, Buck C, Moore PS. Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays. Int J Cancer, 2009. 125:1250-1256. PMCID: PMC2747737. Full text

Shuda, M., R. Arora, H. J. Kwun, H. Feng, R. Sarid, M. T. Fernandez-Figueras, Y. Tolstov, O. Gjoerup, M. M. Mansukhani, S. H. Swerdlow, P. M. Chaudhary, J. M. Kirkwood, M. A. Nalesnik, J. A. Kant, L. M. Weiss, P. S. Moore, and Y. Chang. Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors. Int J Cancer 2009.125:1243-9. Full text

Shuda M, Feng H, Kwun H, Rosen ST, Gjoerup O, Moore PS, Chang Y. T-antigen mutations are a tumor-specific signature for Merkel cell polyomavirus. Proc Natl Acad Sci, USA. 2008 Oct 21;105(42):16272-7. PMCID: 2551627. Free text link

Feng H, Shuda M, Chang Y and Moore PS. Clonal Integration of a Polyomavirus in Merkel Cell Carcinoma. Science February 22 2008: Vol. 319. no. 5866. View abstract; View full text

Chang Y, Jaffe H, Moore PS. Transmission of human herpesvirus 8 by blood transfusion (letter). N Engl J Med 2007; 356:88

Kwun H, Ramos da Silva S, Shaw I, Blake N, Moore PS, Chang Y. KSHV LANA1 mimics EBV EBNA1 immune evasion through central repeat domain effects on protein processing. J Virol 2007;81 (15):8225-35. [PDF]

Feng H, Taylor JL, Benos PV, Newton R, Waddell K, Lucas SB, Chang Y, and Moore PS. Human Transcriptome subtraction using short sequence tags to search for tumor viruses in conjunctival carcinoma. J Virol. 2007 Oct:81 (20):11332-40. [PDF]

Laney AS, Peters J., Manzi S., Kingsley L., Chang Y., Moore P.S. Diagnosis of Kaposi's sarcoma-associated herpesvirus infection (KSHV/HHV8) using a multiantigen detection algorithm J Clin Micro 2006 Oct;44(10):3734-41. [PDF]

Corte-Real S, Collins C, Aires da Silva F, Simas JP, Barbas C, Chang Y, Moore P, Goncalves J. Intrabodies targeting the Kaposi’s sarcoma-associated herpesvirus latency antigen inhibit viral persistence. Blood 2005; 106(12):3797-802 [PDF]

Laney AS, De Marco T, Peters JS, Malloy M, Teehankee C, Moore PS, Chang Y. Kaposi sarcoma-associated herpesvirus and primary and secondary pulmonary hypertension. Chest 2005; 127(3):762-7 [PDF]

Taylor JL, Bennett HN, Snyder BA, Moore PS, and Chang Y. Transcriptional analysis of the latent and inducible KSHV transcripts in the K4-K7 region. J Virol 2005; 79(24):15099-106 [PDF]

Moore PS, Chang Y. Kaposi‘s Sarcoma-Associated Herpesvirus Immunoevasion and Tumorgensis: Two Sides of the Same Coin? Ann Rev Microbiol. 2003;57:609-39. [PDF]

Chatterjee M, Osborne J, Bestetti G, Chang Y. Moore PS. Viral IL-6-Induced Cell Proliferation and Immune Evasion of Interferon Activity.  Science 2002; 298:1432-5  [pdf]  [Supplement pdf]

Boshoff C, Chang Y. Kaposi' sarcoma-associated herpesvirus: A new DNA tumor virus. Annu Rev Med 2001; 52:453-470   [pdf]

Moore PS, Chang Y. Molecular virology of Kaposi's sarcoma-associated herpesvirus. Philos Trans R Soc Lond B Biol Sci 2001; 356:499-516  [pdf]

Rivas C, Thlick AE, Parravicini C, Moore PS, Chang Y. Kaposi's sarcoma-associated herpesvirus LANA2 is a B-cell-specific latent viral protein that inhibits p53. J Virol 2001; 75:429-3  [pdf]

Antman K, Chang Y. Kaposi's sarcoma. N Engl J Med 2000; 342:1027-38.  [pdf]

Olsen SJ, Sarid R, Chang Y, Moore PS. Evaluation of the latency-associated nuclear antigen (ORF73) of Kaposi's sarcoma-associated herpesvirus by peptide mapping and bacterially expressed recombinant western blot assay. J Infect Dis 2000; 182:306-10.  [pdf]

Parravicini C, Chandran B, Corbellino M, et al. Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Am J Pathol 2000; 156:743-9.  [pdf]    

Stine JT, Wood C, Hill M, et al. KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells. Blood 2000; 95:1151-7   [pdf]  

Aoki Y, Jaffe ES, Chang Y, Jones K, Teruya-Feldstein J, Moore PS, et al. Angiogenesis and hematopoiesis induced by Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6. Blood 1999;93(12):4034-43  [pdf]  

Jones KD, Aoki Y, Chang Y, Moore PS, Yarchoan R, Tosato G. Involvement of IL-10 and viral IL-6 in the spontaneous growth of Kaposi's sarcoma herpesvirus-infected body cavity lymphoma cells. Blood 1999; 94(8):2871-79  [pdf]

Schulz TF, Moore PS.   Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how? Trends Microbiol.1999;7(5):196-200.   [pdf]

Sarid R, Wiezorek JS, Moore PS, Chang Y. Characterization and cell cycle regulation of the major Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) latent genes and their promoter. J Virol 1999; 73:1438-46  J. Virol. 1999;73:1438-46   [pdf]

Moore PS, Chang Y. Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV. Trends Genetics 1998;14(4):144-50   [pdf]

Olsen SJ, Tarte K, Sherman W, et al. Evidence against KSHV infection in the pathogenesis of multiple myeloma. Virus Res 1998; 57:197-202   [pdf]

Moore, PS. Human herpesvirus 8 variants (or KSHV and Waterbuffaloes). Lancet 1998; 351:Feb. 28 issue . 

Sarid R, Flore O. Bohenzky RA, Chang Y. Moore PS. Transcriptional mapping of the Kaposi's sarcoma-associated herpesvirus (KSHV) genome in the body cavity-based lymphoma cell line BC-1. J. Virol., 1998: 72:1005-12   [pdf] 

Boshoff C, Endo Y, Collins PD, Takeuchi Y, Reeves JD, Schweickart VL, Siani M, Sasaki T, Williams TJ, Gray PW, Moore PS, Chang Y, Weiss RA. Angiogenic and HIV inhibitory functions of KSHV-encoded chemokines. Science 1997; 278:290-4   [pdf] 

Molden J, Chang Y, You Y, Moore PS, Goldsmith MA. A Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit. Journal of Biological Chemistry 1997; 272:19625-31   [pdf]

Gao S-J, Boshoff C, Jayachandra S, Weiss RA, Chang Y, Moore PS. KSHV ORF K9 (vIRF) is an oncogene that inhibits the interferon signaling pathway. Oncogene 1997; 15:1979-86   [pdf]

Rainbow L, Platt GM, Simpson GR, et al. The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen. J Virol 1997; 71:5915-21  [pdf]

Parravicini C, Olsen SJ, Capra M, et al. Risk of Kaposi's sarcoma-associated herpesvirus transmission from donor allografts among Italian posttransplant Kaposi's sarcoma patients. Blood 1997; 90:2826-9  [pdf]

Sarid R, Sato T, Bohenzky RA, Russo JJ, Chang Y. Kaposi's sarcoma-associated herpesvirus encodes a functional bcl-2 homologue. Nature Med 1997; 3:293-8

Moore PS, Kingsley LA, Holmberg SD, Spira T, Gupta P, Hoover DR, Parry JP, Conley LJ, Jaffe HW, Chang Y. Kaposi's sarcoma-associated herpesvirus infection prior to onset of Kaposi's sarcoma. AIDS. 1996 Feb;10(2):175-80.

Gao SJ, Kingsley L, Li M, Zheng W, Parravicini C, Ziegler J, Newton R, Rinaldo CR, Saah A, Phair J, Detels R, Chang Y, Moore PS. KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma. Nat Med. 1996 Aug;2(8):925-8.

Chang Y, Moore PS, Talbot SJ, Boshoff CH, Zarkowska T, Godden-Kent, Paterson H, Weiss RA, Mittnacht S. Cyclin encoded by KS herpesvirus. Nature 1996; 382:410 [pdf]

Simpson GR, Schulz TF, Whitby D, et al. Prevalence of Kaposi's sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen. Lancet 1996; 348:1133-8   [pdf]

Moore PS, Boshoff C, Weiss RA, Chang Y. Molecular mimicry of human cytokine and cytokine-response pathway genes by KSHV. Science 1996; 274:1739-44  [pdf]

Russo JJ, Bohenzky RA, Chien M, Chen K, Yan M, Maddalena D, Parry JP, Peruzzi D, Edelman IS, Chang Y, Moore PS. The nucleotide sequence of Kaposi's sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci, USA 1996; 93:148627  [pdf]

Gao S-J, Moore PS. Molecular approaches to the identification of  unculturable infectious agents. Emerging Infect Dis 1996; 2:159-67  [pdf]

Simpson GR, Schulz TF, Whitby D, et al. Prevalence of Kaposi's sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen. Lancet 1996; 348:1133-8 [pdf]

Gao SJ, Kingsley L, Li M, Zhang W, Parravicini C, Ziegler J, Newton R, Rinaldo CR, Saah A, Phair J, Detels R, Chang Y, Moore PS KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma. Nature Medicine 1996; 2:925-28 [pdf]

Gao SJ, Kingsley L, Hoover D, Spira T, Rinaldo C, Saah A, Phair J, Detels R, Parry P, Chang Y, Moore PS. Seroconversion to antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcoma. New Eng. J. Med., 1996; 335:233-41  [pdf]

Miller G, Rigsby MO, Heston L, Grogan E, Sun R, Metroka C, Levy JA, Gao S-J, Chang Y, Moore PS. Antibodies to butyrate inducible antigens of Kaposi's sarcoma-associated herpesvirus in HIV-1 infected patients. New Eng. J. Med., 1996; 334:1292-7   [pdf]

Moore PS and Chang Y. Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma from persons with and without HIV infection. New Eng. J. Med., 1995; 332:1181-85 [pdf]

Cesarman E, Chang Y, Moore PS, Said J, Knowles DM. Kaposi's sarcoma-associated herpesvirus-like DNA sequences are detectable in AIDS-related body cavity based non-Hodgkin's lymphomas. New Eng J Med, 1995; 332:1186-91  [pdf]  

PS Moore, SJ Gao, G Dominguez, E Cesarman, O Lungu, DM Knowles, R Garber, PE Pellett, DJ McGeoch and Y Chang. Primary characterization of a herpesvirus agent associated with Kaposi's sarcoma [published erratum appears in J. Virol 1996 Dec; 70(12): 9083]. J. Virol 1996; 70: 549-58   [pdf] 

E Cesarman, PS Moore, PH Rao, G Inghirami, DM Knowles, and Y Chang In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences Blood, Oct 1995; 86: 2708 - 2714. [pdf].

Chang Y, Cesarman E, Pessin MS, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 1994; 265:1865-69  [pdf]