We are working hard to make new discoveries about Merkel Cell Polyomavirus. If you or someone you love has been diagnosed with MCC, check out our page for patients and friends for resources and information.

 

 

 

 

KSHV LANA generates novel cytoplasmic proteins through non canonical translation initiation J Virol. 2012 Dec 19

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Dr. Reety Arora defends her PhD thesis and publishes a killer paper in Science Translational Medicine. Congratulations, Reety! Badhai ho!

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Check out Human Herpesviruses:

Patrick S. Moore, MD, MPH

Patrick Moore

Director, Cancer Virology Program
American Cancer Society Research Professor
Professor, Department of Microbiology and Medical Genetics

Office Phone: 412-623-7721, -7718
Lab Phone: 412-623-7733
Fax: 412-623-7715
Email: psm9@pitt.edu

Lab Address:
Hillman Cancer Research Pavilion
Suite 1.8
5117 Centre Ave.
Pittsburgh, PA 15213

 


ACADEMIC APPOINTMENTS:

2002-present

Director, Molecular Virology Program, UPCI Professor, Molecular Genetics and Biochemistry
University of Pittsburgh, Pittsburgh, PA

1998-2002 Professor of Public Health Division of Epidemiology
Columbia University, New York, NY
1995-1998 Associate Professor of Public Health Division of Epidemiology Columbia University, New York, NY
1994-1995 Assistant Professor of Public Health Division of Epidemiology Columbia University, New York, NY

PRIOR EXPERIENCE:

1993-1994 Deputy Commissioner
New York City Department of Health, New York, NY
1991-1993 Chief, Epidemiology Section:
Arboviral Diseases Branch, Centers for Disease Control,
Fort Collins, CO
1989-1991 MPH; University of California, Berkley
AIDS Prevention Studies (CAPS) Scholar
1987-1989 Epidemic Intelligence Service (EIS) Officer,
Meningitis and Special Pathogens Branch,
Centers for Disease Control and Prevention (CDC)
1986-1986 Research Physician: Onchocerciasis Research Project
LAC, Liberia (Case Western Reserve University)
1985-1985 Medical Officer: Bawku Presbyterian Hospital, Ghana

Biosketch: Patrick S. Moore, MD, MPH is an American Cancer Society (ACS) Professor in the Department of Microbiology and Molecular Genetics, University of Pittsburgh. He is Director of the Cancer Virology Program for the University of Pittsburgh Cancer Institute. Dr. Moore is recognized for his role, together with Dr. Yuan Chang—also an ACS Professor, in discovering and characterizing Kaposi sarcoma herpesvirus (KSHV or HHV8) and Merkel cell polyomavirus (MCV), the two most recently recognized human tumor viruses. Dr. Moore and Chang’s laboratory maintain an active focus on basic and translational research for both KSHV and MCV. Dr. Moore has received the General Motors Cancer Research Foundation Mott Award, the Robert Koch Prize, the Meyenburg Cancer Research Prize as well as other awards, and 21 patents. He is a Thomson Reuter ISI Highly Cited Researcher with over 12,000 scientific citations since 1992. He received medical and graduate degrees from the University of Utah, Stanford University and University California, Berkeley and trained at the Centers for Disease Control as an Epidemic Intelligence Service (EIS) officer.

Selected Publications:

  1. Feng H, Shuda M, Chang Y, Moore PS. Clonal Integration of a Polyomavirus in Merkel Cell Carcinoma. Science 2008:319; 1096-1100.
  2. Shuda M, Feng H, Kwun H, Rosen ST, Gjoerup O, Moore PS, Chang Y. T-antigen mutations are a tumor-specific signature for Merkel cell polyomavirus. Proc Natl Acad Sci, USA. 2008;105(42):16272-7. PMCID: 2551627.
  3. Shuda, M., R. Arora, H. J. Kwun, H. Feng, R. Sarid, M. T. Fernandez-Figueras, Y. Tolstov, O. Gjoerup, M. M. Mansukhani, S. H. Swerdlow, P. M. Chaudhary, J. M. Kirkwood, M. A. Nalesnik, J. A. Kant, L. M. Weiss, P. S. Moore, and Y. Chang. Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors. Int J Cancer 2009;125:1243-9.
  4. Tolstov Y, Pastrana D, Feng H, Becker J, Jenkins F, Moschos S, Chang Y, Buck C, Moore PS. Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays Int J Cancer 2009;125:1250-1256.
  5. Busam K, Jungbluth AA, Rekhtman N, Coit D, Pulitzer M, Bini JM, Arora R, Hanson NC, Tassello JA, Frosina D, Moore P, Chang Y. Merkel cell polyomavirus expression in merkel cell carcinomas and its absence in combined tumors and pulmonary neuroendocrine carcinomas.2009 Am J Surg Path 2009;33(9):1378-85.
  6. Pastrana, DV, Tolstov YL, Becker JC, Moore PS, Chang Y, and Buck CB. Quantitation of human seroresponsiveness to Merkel cell polyomavirus. PLoS Pathog 2009 In Press
  7. Kwun HJ, Guastafierro A, Shuda M, Meinke G, Bohm A, Moore PS, and Chang Y. The minimum replication origin of Merkel cell polyomavirus has a unique large T antigen loading architecture and requires small T antigen expression for optimal replication. J Virol 2009 In Press.
  8. Li Z, Kim SW, Lin Y, Moore PS, Chang Y, John B. Characterization of viral and human RNAs smaller than canonical microRNAs. J Virol 2009 83(24):12751-12578.
  9. Kwun HJ, Guastafierro A, Shuda M, Meinke G, Bohm A, Moore PS, and Chang Y. The minimum replication origin of Merkel cell polyomavirus has a unique large T antigen loading architecture and requires small T antigen expression for optimal replication. J Virol, 2009 Dec;83(23):12118-28.
  10. Pastrana, DV, Tolstov YL, Becker JC, Moore PS, Chang Y, and Buck CB. Quantitation of human seroresponsiveness to Merkel cell polyomavirus. PLoS Pathog, 2009. Sept;5(9):e1000578.
  11. Moschos S, Chang Y, and Moore PS. Merkel Cell Polyomavirus: The Seventh Human Cancer Virus? The Melanoma Letter, 2009 Summer;27(2).
  12. Kim S, Li Z, Moore PS, Monaghan A, Chang Y, Nichols M, John B. A sensitive nonradioactive northern blot method to detect small RNAs. Nuc Acids Research, 2010 Apr 1;38(7):e98. Epub 2010 Jan 15.