We are working hard to make new discoveries about Merkel Cell Polyomavirus. If you or someone you love has been diagnosed with MCC, check out our page for patients and friends for resources and information.

If you'd like to be contacted to learn more, email our Study Coordinator with your contact information and a good time to reach you.

 

 

 

Congratulations to Ezra and Reva on their marriage!
!מזל טוב
(Mazal Tov!)

Welcome to the Chang-Moore Lab Homepage

Welcome to the home page of Dr. Yuan Chang and Dr. Patrick Moore’s laboratory.

The Chang-Moore Laboratory in the Cancer Virology Program at the University of Pittsburgh Cancer Institute is responsible for discovering the viral causes of four different human cancers. In 1994, Chang-Moore lab identified and isolated Kaposi’s sarcoma-associated herpesvirus (KSHV) causing this epidemic cancer among HIV/AIDS patients. In addition to KS, KSHV causes primary effusion lymphoma (PEL) and most cases of multicentric Castleman’s disease (MCD). The Chang-Moore lab also developed a new technology (digital transcriptome subtraction, or DTS) for identifying human cancer viruses and in 2008 discovered Merkel cell polyomavirus (MCV) causing most Merkel cell carcinomas. Drs. Moore and Chang are a husband and wife research team.

Research in the Chang-Moore laboratory ranges from basic biological investigations into how cells become cancerous to epidemiologic/clinical research into the diagnosis, treatment and prevention of cancers caused by viruses.

For a video introduction to our research, click here. To know more, please visit the KSHV and MCV pages and feel free to contact us for more information.